P194 Comparing Vitamin D levels in patients with COVID-19 and tuberculosis infection

IntroductionVitamin D is important in innate and adaptive immunity Deficiency is associated with susceptibility to tuberculosis(TB) and viral respiratory tract infections Prevalence increases in patients of Black and Asian ethnicity, high BMI, smokers and the elderly Vitamin D deficiency may have a role in acquisition and severity of COVID-19 infection ObjectiveTo investigate vitamin D status in patients admitted to hospital and critical care with COVID-19, and to compare vitamin D levels to patients with TB infection MethodsVitamin D levels were measured prospectively in adult patients admitted to three medical wards and HDU/ITU with suspected COVID-19 infection between 6/4/20 and 4/5/20 Data was supplemented by retrospectively screening admissions between 1/3/20 and 31/5/20 with PCR confirmed COVID-19 infection or highly suggestive chest radiology with a Vitamin D level within 3 months Adult patients treated for latent and active TB between 1/1/18 to 30/6/20 had Vitamin D levels measured at treatment start Patients were stratified as Vitamin D deficient(50 nmol) ResultsVitamin D levels were available for 244/551(44%) patients admitted with confirmed COVID-19, including 62/113(55%) ITU/HDU admissions, and for 230/237(97%) TB patients Overall, 195/244(76%) inpatients with COVID-19 had vitamin D 30 kg/m2 Vitamin D levels were not lower in COVID-19 patients requiring respiratory support or those that died- 76% of discharged patients were insufficient/deficient, compared to 69% requiring respiratory support and 70% that died There was no significant difference in proportion of insufficient/deficient patients with ethnicity- White 89/120(74%), Black 52/68(76%), Asian 11/14(78%) Patients with active TB had lower vitamin D than patients with latent infection, but similar levels to patients with COVID-19(median 28 5 mol, 51% deficient, vs 40 8 nmol, 17% deficient vs 29 nmol, 43% deficient) ConclusionThree-quarters of patients admitted with COVID-19 had low Vitamin D levels, proportionately similar to patients with TB infection There was no correlation with disease severity