Method for preparing PLGA microspheres with porous surfaces

The invention provides a method for preparing PLGA microspheres with the porous surfaces. The method includes the steps that PLGA is added into an organic solvent, stirred and dissolved, a hole forming solution is dropwise added into the mixture, the mixture is subjected to ultrasonic emulsification, and emulsified liquid is formed, wherein the molar ratio of LA to GA of the PLGA ranges from 50:50 to 90:10; the emulsified liquid is dropwise added into a stirring external water phase, preset-volume deionized water is added, and continuous stirring is conducted at changed speeds till the organic solvent is completely volatilized, wherein the external water phase is formed in the mode that a water-soluble surfactant is added into deionized water; the solution obtained after the organic solvent is completely volatilized is centrifuged, and washed with the deionized water, supernatant liquid is removed, and the PLGA microspheres are obtained; a NaOH solution is added into the PLGA microspheres, and the mixture is mixed to be even and placed to a shaking table to continue to be reacted; the reacted PLGA microspheres are centrifuged and washed with deionized water repeatedly, and frozen and dried, and the PLGA microspheres with the porous surfaces are obtained. The method is simple in technology, short in period and suitable for industrialized mass production.