Ca 2+ permeation and/or binding to Ca V 1.1 fine-tunes skeletal muscle Ca 2+ signaling to sustain muscle function

Background Ca2+ influx through CaV1.1 is not required for skeletal muscle excitation-contraction coupling, but whether Ca2+ permeation through CaV1.1 during sustained muscle activity plays a functional role in mammalian skeletal muscle has not been assessed.