Pharmacologic modulation of human cerebral activity: contribution of functional neuroimaging.

This article highlights the following: (1) How the tools of functional neuroimaging analyze the effect of drug therapy on the central nervous system; (2) how the interactions between the drugs and the cortical neuronal networks have illustrated new aspects of the concepts of cerebral neuroplasticity; and (3) how functional neuroimaging has proved to be a valuable tool in understanding the mechanisms that govern the therapeutic activity of experimental drugs.