Effects of perilla frutescens seed supplemented to diet on fatty acid composition and lipogenic gene expression in muscle and liver of Hu lambs

Abstract The objective of this study was to determine the effect of perilla ( perilla frutescens L.) seed (PFS) supplementation on serum lipids metabolism, intramuscular adipocyte size, fatty acid composition and lipogenic genes expression in muscle and liver of Hu lambs. Sixty male Hu lambs (23.02 ± 1.36 kg body weight and approximately 3 months of age) were randomly assigned to four dietary treatments receiving diets containing 0%, 5%, 10% or 15% perilla seed (CD, 5%PFSD, 10%PFSD and 15%PFSD, respectively). During the 84 days experimental period, these groups were fed the assigned diets ad libitum . Compared with CD group, LDL-cholesterol, total cholesterol, and triglyceride levels in the serum significantly (P  longissimus muscle and liver (P  cis 9, linoleic acid (LA), and total saturated fatty acids (SFA) and n-6 to n-3 ratio decreased in muscle and liver in PFS groups compared with CD group (P  PPARα and PPARγ expression and significantly decreased LPL , ACC , FASN , SCD , FADS 1, and FADS2 expression (P