Deep-learning analysis of H&E images to define three immune phenotypes to reveal loss-of-target in excluded immune cells as a novel resistance mechanism of immune checkpoint inhibitor in non-small cell lung cancer.

Sehhoon Park,Chan-Young Ock,Minje Jang,Jiwon Shin,Sarah Lee,Kyunghyun Paeng,Jonghanne Park,Young Kwang Chae,Yoon-La Choi,Tony Mok,Se-Hoon Lee

Deep-learning analysis of H&E images to define three immune phenotypes to reveal loss-of-target in excluded immune cells as a novel resistance mechanism of immune checkpoint inhibitor in non-small cell lung cancer.

2020

Sehhoon Park
Chan-Young Ock
Minje Jang
Jiwon Shin
Sarah Lee
Kyunghyun Paeng
Jonghanne Park
Young Kwang Chae
Yoon-La Choi
Tony Mok
Se-Hoon Lee

3120Background: Discovery of predictive biomarker to enrich the responder of immune checkpoint inhibitor (ICI) in PD-L1-low ( < 50%) non-small cell lung cancer (NSCLC) is still challenging. Recent ...

Keywords:

Cancer research
Lung cancer
Immune system
non small cell
Phenotype
Medicine
immune checkpoint inhibitors
Pathology

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