Midazolam Administration Reverses Thermal Hyperalgesia and Prevents γ-Aminobutyric Acid Transporter Loss in a Rodent Model of Neuropathic Pain

Background Loss of GABA inhibition in the spinal dorsal horn may contribute to neuropathic pain. Here we examined whether systemic administration of the benzodiazepine midazolam would alleviate thermal hyperalgesia due to chronic constriction injury (CCI) of the sciatic nerve.