Bullous fixed drug eruption in a patient with metastatic renal cell carcinoma induced by iodinated contrast during pazopanib treatment

Hypersensitivity reactions due to iodinated contrast media is well known by clinicians, however, little is known of fixed drug eruptions.A 70-year-old man underwent nephrectomy because of a T3aG2N2 clear-cell renal cell carcinoma. During post-operative follow-up, retroperitoneal lymphadenopathy was detected. Treatment with sunitinib (a tyrosine kinase inhibitor) was initiated, based on an intermediate risk classification according to the Motzer criteria [1]. After 6 months of therapy a CT-scan was [...]