POORLY DIFFERENTIATED SQUAMOUS CELL CARCINOMA IN THE SUBMANDIBULAR SALIVARY GLAND REGION: AN UNCOMMON CASE REPORT

A 70-year-old male patient had complaints of pain in the right side of the face after tooth extraction with 7-month evolution. The extraoral physical examination revealed increase of volume in right submandibular region that was hardened and painful with negative aspiration. The clinical diagnosis of chronic inflammatory process or dermoid cyst were established, and an incisional biopsy was performed, which revealed malignant neoplasm of epithelial origin evidenced by positive stain for antibodies AE1/AE3, CK7, high-molecular-weight CK, p40, and negative for thyroid transcription factor (TTF)–1e gross cystic disease fluid protein (GCDFP)–15. Afterward, the patient was referred to the oncology service in which surgical removal and cervical emptying were performed, showing lymph node metastasis and perineural and angiolymphatic invasion, invading the dermis without continuity of salivary gland tissue with the lesion. There was no previous history of other carcinomas, and final diagnosis was poorly differentiated squamous cell carcinoma. The patient is still on regular follow-up at an interval of 2 months.