Abstract 14879: High dose Vitamin D Supplementation Attenuates Left Atrial Enlargement in African American Men with Hypovitaminosis D and Dysglycemia: Results of the D-Vitamin Intervention in Veteran Administration (DIVA) Randomized Controlled Trial

Introduction: Vitamin D deficiency is common among African American men (AAM) in the United States and is associated with increased cardiovascular disease risk. This study evaluated the effect of high-dose vitamin D supplementation on echocardiographic parameters in AAM with dysglycemia and hypovitaminosis D. Hypothesis: High dose vitamin D therapy will improve structural and diastolic echocardiographic parameters. Methods: AAM with dysglycemia (A1C 5.7-6.9% and no hypoglycemic drugs) and low vitamin D levels (25OHD: 5.0-29ng/ml) were randomized to high-dose ergocalciferol (50,000 IU/week) or placebo. Echocardiography was performed at baseline and at 1 year. Ejection fraction (EF), septal and posterior wall thickness, left ventricular end diastolic diameter (LVEDd), left ventricular end systolic diameter (LVEDs), left atrial (LA) area, LA length, LA volume, E, A, septal and lateral e’ and a’, deceleration time (DT), and isovolumetric relaxation time (IVRT) were measured. Results: 81/158 (51%) patients rec...