Amorphous teneligliptin hydrobromide and preparation method thereof

Provided is an amorphous teneligliptin 2.5 hydrobromide and a preparation method thereof. The method includes: rotary evaporation of a teneligliptin 2.5 hydrobromide hydrate under a certain water bath temperature by using a rotary evaporator; or dissolving a teneligliptin 2.5 hydrobromide hydrate into a solvent, and spray-drying the solution by using a spray dyer; or freeze drying a teneligliptin 2.5 hydrobromide hydrate solution, to prepare the amorphous teneligliptin 2.5 hydrobromide. The method is simple, efficient, and economical, the quality of the intermediate can be controlled, and the method is suitable for industrial preparation. The prepared preparation product is stable.