In vivo topical anti-inflammatory and wound healing activities of the fixed oil of Caryocar coriaceum Wittm. seeds

Abstract Ethnopharmacological relevance Caryocar coriaceum Wittm. (Caryocaraceae), popularly known as pequi, is important source of food and used in the folk medicine as wound healing, anti-inflammatory and for the treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer. Aim of the study To evaluate the effects of fixed oil of Caryocar coriaceum (FOCC) on the topical inflammation and cutaneous wound healing. Materials and methods FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% on model of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excision model in mice. Skin lesions were evaluated by planimetry and histological analysis. Results FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%) inhibited the ear edema in 38.01% and 39.20% at time 15 min and 1 h, respectively, after induction of inflammation, when compared to the positive control. The topical administration of FOCC ointment 12% showed a significantly reduction of unhealed wound area, with increased percentage of wound contraction (96.54%) on day 7 when compared to the other groups. The results of histological evaluation supported the outcome of excision wound model. Conclusion Caryocar coriaceum inhibits the topical inflammation and accelerate cutaneous wound repair.