Delayed Model for HIV Infection with Drug Effects

Delayed models are a better representation of the nature of HIV. In the present paper, a multi-delayed model of HIV with combination drug therapy has been analysed. Effect of the immune response in the form of effector cell response has also been included to make the model more justified. The threshold properties related with the basic reproduction number \(R_0\) have been discussed. The local and global properties of the model have been analysed. Extensive numerical simulations have been performed to show the impact of highly effective drug on the concentration of virus. The numerical simulations and the result proved has led to the conclusion that a highly effective drug when combined with a less effective drug, can very efficiently bring down the viral load to undetectable levels.