Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain.

Paolo Zanotti-Fregonara,Vanessa N. Barth,Jeih-San Liow,Sami S. Zoghbi,David T. Clark,Emily Rhoads,Edward R. Siuda,Beverly A. Heinz,Eric S. Nisenbaum,Bruce A. Dressman,Elizabeth M. Joshi,Debra Luffer-Atlas,Matthew Joseph Fisher,John Joseph Masters,Nancy Goebl,Steven Lee Kuklish,Cheryl L. Morse,Johannes Tauscher,Victor W. Pike,Robert B. Innis

Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain.

2013

Purpose Two allosteric modulators of the group I metabotropic glutamate receptors (mGluR1 and mGluR5) were evaluated as positron emission tomography (PET) radioligands for mGluR1.

Keywords:

Pathology
Medicine
Blood–brain barrier
Positron emission tomography
Allosteric regulation
In vitro
Metabotropic glutamate receptor 5
Nuclear medicine
Pharmacology
Radioligand
Metabotropic glutamate receptor
Metabotropic glutamate receptor 1

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