Antibacterial C-Geranylflavonoids from Paulownia tomentosa Fruits
2008
Eight C-6-geranylflavonoids (1-8) were isolated from an ethanol
extract of Paulownia tomentosa fruits. Tomentodiplacone (1),
3-O-methyl-5-hydroxydiplacone (2),
3-O-methyl-5-O-methyldiplacone (3), and tomentodiplacone B (4)
were obtained as new compounds, and 3-O-methyldiplacol (5) was
isolated for the first time from a natural source. The
structures of these new compounds were determined by using mass
spectrometry (including HRMS) and 1D and 2D NMR spectroscopy,
and the absolute configurations of the compounds were
determined by circular dichroism. The antibacterial activities
of 1-8 against seven bacteria and yeast were evaluated.
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