A Phase I, Randomized, Double-Blind, Laser-Evoked Potential Study to Evaluate the Analgesic/Antihyperalgesic Effect of ASP9226, a State-Dependent N-Type Voltage-Gated Calcium Channel Inhibitor, in Healthy Male Subjects

Klaus Schaffler,Weizhong He,Paul Passier,Katherine Tracy,Allam Fakhoury,Jeffrey Paul

A Phase I, Randomized, Double-Blind, Laser-Evoked Potential Study to Evaluate the Analgesic/Antihyperalgesic Effect of ASP9226, a State-Dependent N-Type Voltage-Gated Calcium Channel Inhibitor, in Healthy Male Subjects

2018

Klaus Schaffler
Weizhong He
Paul Passier
Katherine Tracy
Allam Fakhoury
Jeffrey Paul

Objective Evaluate the analgesic/antihyperalgesic effects of ASP9226, a state-dependent N-type voltage-gated calcium channel inhibitor, in healthy male subjects.

Keywords:

Anesthesia
Protein tyrosine phosphatase
Pregabalin
Voltage-dependent calcium channel
Laser
Capsaicin
Medicine
Neuropathic pain
Laser-Evoked Potentials
Analgesic
Placebo
Surrogate endpoint
Subgroup analysis
Crossover study
Visual analogue scale

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