Novel Tetrafunctional Probes Identify Target Receptors and Binding Sites of Small-molecule Drugs from Living Systems

Rin Miyajima,Koji Sakai,Yuki Otani,Takashi Wadatsu,Yasuyo Sakata,Yuki Nishikawa,Masaki Tanaka,Yu. Yamashita,Mikayo Hayashi,Kazumi Kondo,Takashi Hayashi

Novel Tetrafunctional Probes Identify Target Receptors and Binding Sites of Small-molecule Drugs from Living Systems

2020

Rin Miyajima
Koji Sakai
Yuki Otani
Takashi Wadatsu
Yasuyo Sakata
Yuki Nishikawa
Masaki Tanaka
Yu. Yamashita
Mikayo Hayashi
Kazumi Kondo
Takashi Hayashi

Significant advancement of chemoproteomics has contributed to uncovering the mechanism of action (MoA) of small-molecule drugs by characterizing drug–protein interactions in living systems. However...

Keywords:

Chemistry
Chemoproteomics
Living systems
Binding site
Small molecule
Biophysics
Receptor
Mechanism of action

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