Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion

Aims/hypothesis Several glucose-sensing pathways have been implicated in glucose-triggered secretion of glucagon-like peptide-1 (GLP-1) from intestinal L cells. One involves glucose metabolism and closure of ATP-sensitive K+ channels, and another exploits the electrogenic nature of Na+-coupled glucose transporters (SGLTs). This study aimed to elucidate the role of these distinct mechanisms in glucose-stimulated GLP-1 secretion.