Prevention and treatment of early rebleeding after endoscopic variceal ligation

Objective To evaluate the preventative and therapeutic effects of drug application on the early rebleeding after EVL.Methods The records of the patients suffered with cirrhosis and/or hepatocellular carcinoma and accepted EVL in our hospital during the past 10 years were summarized.Totally 593 procedures of EVL had been performed in the period.Early rebleeding rate after EVL and death rate after rebleeding were calculated.The medicine application for the prevention of early rebleeding after EVL and the effect were also analyzed.Results The morbidity and mortality of early rebleeding after EVL were 4.7% (13/28) and 64.3% (18/28).The frequency of using proton pump inhibitor,octreotide,membrane protection agents and thrombin increased dramatically by year,but it didn't accompany with the decrease of morbidity and mortality of early rebleeding after EVL.Conclusion Drug prophylaxis doesn't decrease the early rebleeding rate after EVL and the death rate after rebleeding.The death rate after rebleeding may be induced by proton pump inhibitor application.