Can Triggering Receptors on Myeloid Cells be used for Diagnosis of Salmonella typhi Infection

BACKGROUND: There is a need for rapid and accurate diagnostic biomarker for diagnosis of Salmonella fever. AIMS: The aim of the present study was to assess the utility of procalcitonin (PCT), Soluble Triggering Receptors 1 on Myeloid Cells (sTREM1) and C- reactive protein (CRP) in diagnosis of enteric fever with positive blood culture for S.typhi. MATERIALS AND METHODS: Blood samples were withdrawn from 200 patients with suspected enteric fever and subjected for determination of CRP, PCT and sTREM-1. RESULTS: The sensitivity and specificity for PCT cut off was 97.7% &82.5% for each, for CRP the sensitivity and specificity were 95.3% and 77% for each and for s-TREM-1 the sensitivity and specificity were 95.3% & 77%. CONCLUSION: S-TREM-1 may be considered as a novel biomarker for such diagnosis of enteric fever with good sensitivity and specificity.