Cold Atmospheric Plasma (CAP) Combined with Chemo-Radiation and Cytoreductive Surgery: The First Clinical Experience for Stage IV Metastatic Colon Cancer

The authors report the first clinical experience using CAP for Stage IV metastatic colon cancer. The report describes the patient’s history, chemotherapy, radiation, surgical treatment and ex-vivo and intra-operative treatment of the tumor and normal tissue with CAP. Evaluation of intra-operative temperature, oxygen and end tidal CO2 measurements during the surgery and post-surgery analysis of tissue treated by cold plasma. In vivo studies suggest that TRAIl-R1 expression increases in the CAP treated liver tissues, suggesting that the death receptor molecule may be involved in inducing apoptosis. Three-month postoperative CT scan of the abdomen and pelvis revealed no evidence of recurrent tumor at the resected and cold plasma treatment sites.