Neural, Cognitive, and Clinical Effects of Prefrontal Cortex Stimulation in Depression Combined with Psychological Therapy: A Double-Blind Randomized Controlled Trial

Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has recently shown efficacy as a treatment for depression. We combined tDCS with psychological therapy to determine whether tDCS of the DLPFC could enhance therapeutic outcome in depression.