Evaluation of a single dose schedule of 15(S)15 methyl PGF2 alpha methyl ester suppository for the termination of 10–14 weeks of pregnancy

Abstract The abortifacient efficacy of a single vaginal suppository containing 3 mg of 15(S)15 methyl PGF 2 alpha methyl ester in 10 to 14 weeks of pregnancy was evaluated in 58 women. The success rate was 72.4% in the trial period of 30 hours. The mean induction-abortion interval was 17.9 hours in the successful cases. In multigravidas the success rate was found to be comparatively higher with shorter induction-abortion interval in comparison to primigravidas. The episodes of vomiting and diarrhea per patient were 0.8 and 1.4, respectively. The induction-pain interval was significantly higher in failed cases. All the failed cases were aborted vaginally with the supplementary administration of 15(S)15 methyl PGF 2 alpha.