Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes

Abstract The discovery of a novel series of N -arylpyrroles as agonists of GPR120 (FFAR4) is discussed. One lead compound is a potent GPR120 agonist, has good selectivity for related receptor GPR40 (FFAR1), has acceptable PK properties, and is active in 2 models of Type 2 Diabetes in mice.