Improved detection of solitary pulmonary nodules on radiographs compared with deep bone suppression imaging.

Background The present study aimed to investigate whether deep bone suppression imaging (BSI) could increase the diagnostic performance for solitary pulmonary nodule detection compared with digital tomosynthesis (DTS), dual-energy subtraction (DES) radiography, and conventional chest radiography (CCR). Methods A total of 256 patients (123 with a solitary pulmonary nodule, 133 with normal findings) were included in the study. The confidence score of 6 observers determined the presence or absence of pulmonary nodules in each patient. These were first analyzed using a CCR image, then with CCR plus deep BSI, then with CCR plus DES radiography, and finally with DTS images. Receiver-operating characteristic curves were used to evaluate the performance of the 6 observers in the detection of pulmonary nodules. Results For the 6 observers, the average area under the curve improved significantly from 0.717 with CCR to 0.848 with CCR plus deep BSI (P<0.01), 0.834 with CCR plus DES radiography (P<0.01), and 0.939 with DTS (P<0.01). Comparisons between CCR and CCR plus deep BSI found that the sensitivities of the assessments by the 3 residents increased from 53.2% to 69.5% (P=0.014) for nodules located in the upper lung field, from 30.6% to 44.6% (P=0.015) for nodules that were partially/completely obscured by the bone, and from 33.2% to 45.8% (P=0.006) for nodules <10 mm. Conclusions The deep BSI technique can significantly increase the sensitivity of radiology residents for solitary pulmonary nodules compared with CCR. Increased detection was seen mainly for smaller nodules, nodules with partial/complete obscuration, and nodules located in the upper lung field.