Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies

Results from an interspecies scaling study of the elimination half-lives of the anxiolytic GB-115 and the antipsychotic dilept in rats, rabbits, and humans are presented. The elimination half-lives of the studied drugs are calculated in real (chronological) and corrected time (pharmacokinetic). Elimination half-lives in animals and volunteers are compared. Rabbits are found to be a better scaling model for GB-115 although a single preference for dilept was not found.