Methylphenidate and venlafaxine attenuate locomotion in spontaneously hypertensive rats, an animal model of attention-deficit/hyperactivity disorder, through α2-adrenoceptor activation.

Recent clinical studies have shown that serotonin–norepinephrine reuptake inhibitors such as venlafaxine and duloxetine are effective against symptoms of attention–deficit/hyperactivity disorder such as inattention, oppositionality, and hyperactivity. We have recently found that these serotonin–nore