Preclinical safety assessment of Griffithsin-based vaginal microbicides.

iv LIST OF FIGURES vi CHAPTER 1: INTRODUCTION 1 CHAPTER 2: MOUSE SERUM ALBUMIN IS A SENSITIVE MARKER FOR EPITHELIAL DAMAGE IN A MURINE PRECLINICAL MODEL 11 CHAPTER 3: IMMUNOGENICITY OF VAGINALLYAND SYSTEMICALLYADMINISTERED GRFT 33 CHAPTER 4: CONCLUSIONS AND FUTURE DIRECTIONS 48 REFERENCES 52 CURRICULUM VITAE 60