Furacilin Release from Solid Dispersions

The effects of solid dispersions (SDs) on furacilin solubility were studied. Furacilin and its SDs with polyethyleneglycol-1500 (PEG) and polyvinylpyrrolidone-10000 (PVP) were investigated. SD formation doubled furacilin solubility and increased its dissolution rate as the SD with PVP by 12 times compared with furacilin powder. It was supposed that several factors were responsible for the improved release of furacilin from the SD. These included reduced crystallinity, amorphization, and intermolecular interactions, presumably H-bonds.