Interethnic Differences in Drug Response: The Contribution of Genetic Variability in β Adrenergic Receptor and Cytochrome P4502C9

Ethnic differences in drug response have been extensively reported, and ethnicity has been suggested to be useful clinically as a predictor of drug response. Genetic polymorphisms in the genes encoding β1 adrenergic receptor (AR) and β2 AR, targets of β AR antagonists, and in cytochrome P4502C9, the enzyme involved in warfarin metabolism, have the potential to explain some of the observed ethnic variability in drug response and to improve clinical practice. Clinical Pharmacology & Therapeutics (2007) 82 215–218; doi:10.1038/sj.clpt.6100142; published online 28 February 2007