Denosumab and the current status of bone-modifying drugs in breast cancer

AbstractBackground. Bone-modifying therapy is a primary research interest in breast cancer. Several features contribute to the importance of the bone environment in the management of breast cancer. Firstly, bone metastases represent the most common site of breast cancer metastases and secondly, the emergence of cancer treatment-induced bone loss (CTIBL) among breast cancer survivors and patients is of increasing concern. Furthermore, concordant with the “seed and soil” theory, agents that alter the bone microenvironment may even prevent tumor cell seeding in bone and limit cancer growth. Material and methods. Medical databases and conference proceedings were searched to identify articles, abstracts and clinical trials that have or are investigating denosumab and bisphosphonates in cancer therapy. Our search included a predefined focus on bone-modifying therapies in early and advanced breast cancer. Results and discussion. Bisphosphonates (BPs) have an established role both in the prevention and treatment ...