BIOPHYSICAL AND BIOCHEMICAL MODULATORS ASSOCIATED WITH HEALING OF THE OSSEOUS TISSUE

Introduction: Fracture is a bone loss that can be discovered by pathological factors, congenital diseases, avitaminosis or even surgeries, and the cicatricial process as recovery of tissue stability. We have the possibility of assisting in the healing of the bone tissue of biochemical and biophysical modulators, from the use of hydroxyapathy, chitosone, ultrasound and cryotherapy. Objective: This literature review aimed to discuss the characteristics of bone tissue, its regeneration and the main biochemical and biophysical treatments without the use of auxiliary agents in the cicatricial process. Methodology: A research of data on PubMed, SciELO, LILACS, Journal of Cell Science and the Ministerio da saude was done through the keywords “Bone healing”, “Modulators” and its components in Portuguese and English, in the last 10 years. 92 articles were found, with 43 articles selected. Results: According to the studies of literary bases, the biochemical and biochemical ones were constituted and are great auxiliaries in the cicatricial process of the bone tissue. Conclusion: Evidence in the literature has shown that modulators can reduce the time of regeneration of bone tissue.