Monosomy 22 and Trisomy 14 May Be Early Events in the Tumorigenesis of Adult Granulosa Cell Tumor

Abstract The finding of monosomy 22 and trisomy 14 in a case of adult type of granulosa-thecoma cell tumor and the available information from the literature allow for the hypothesis that, especially monosomy 22, but also trisomy 14, may be early events in the tumorigenesis of adult sex cord-stromal tumors in general, and of granulosa-thecoma cell tumors in particular.