Clinical observations of cerebrospinal fluid wound leakage after posterior cranial fossa craniotomy which using synthetic dural substitute and autologous anadesma in dural closure and reconstruction

Objective To explore whether using the Neuro-Patch or autologous anadesma in dural closure and reconstruction could reduce the incidence of cerebrospinal fluid wound leakage after the posterior cranial fossa craniotomy.Methods Clinical data of 165 patients with the posterior cranial fossa craniotomy were analyzed retrospectively,including The traditional craniotomy group,Neuro-Patch group,and Autologous anadesma group.The incidence of cerebrospinal fluid wound leak of three groups was reviewed comparatively.Results In the traditional craniotomy group,cerebrospinal fluid wound leakage occurred in 14(26.9%),compared to the 7 in Neuro-Patch group(10.6%),and 4 in Autologous group(8.5%).Conclusions Dural watertight suture is the correct therapeutic strategy to reduce the incidence of cerebrospinal fluid wound leakage.There is no difference in the effect of use the Neuro-Patch or autologous anadesma to reduce the incidence rate of this complication.The Neuro-Patch is a reliable dural substitute for repairing the dural defects.