Reflux Inhibitors and Prokinetics

Gastro-oesophageal reflux disease (GORD) is a motility disorder that develops when reflux of stomach contents causes troublesome symptoms or complications [1]. This syndrome encompasses a broad range of pathological conditions in which reflux is the root cause of oesophageal or extra-oesophageal problems. Several factors are considered important in the pathophysiology of GORD, including the occurrence of reflux, refluxate constituents, clearance of refluxate, and oesophageal mucosal sensitivity [2]. The roles of each factor vary among individuals and respiratory conditions [3], and contribute to the heterogeneity of this syndrome.