P812 NOX2-GENERATED OXIDATIVE STRESS IS INCREASED IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE INDEPENDENTLY FROM METABOLIC SYNDROME

Background and Aims: Non-Alcoholic Fatty Liver Disease (NAFLD) has a spectrum of disease severity beginning with steatosis. However, descriptions of prevalence and patient follow-up data are minimal. The aim was to determine the prevalence of hepatic steatosis using accepted computed tomography (CT) criteria, and to determine the follow-up rate of radiology-reported steatosis. Methods: A retrospective chart review was performed on all afterhours chest or abdominal CT scans in London, Canada, between January 1 and July 31, 2011. Follow-up was determined by electronic chart review and by contacting patients’ family physicians. Liver and spleen attenuation was calculated using accepted CT criteria to determine steatosis. Results: Over a 6-month period in 2011, 1259 Emergency Room CT Scans were performed, 450 met inclusion criteria. Forty-eight patients had reported findings of steatosis. No patients had followup bloodwork or testing and 2 of 48 patients had follow-up arranged with their family physician. Four hundred and five patients were included in the attenuation analysis. One hundred of the 405 included patients (24.7%) met CT criteria for steatosis (40/46 with radiology-reported steatosis and 60/359 without reported steatosis). Radiologist reporting of the incidental-steatosis had a sensitivity of 40% and specificity of 98% when compared to CT criteria for steatosis. Conclusions: This study was the first to provide steatosis prevalence data in Canada. The prevalence reported here is above the global average, but below reported American prevalences. Under-reporting and lack of follow-up on reported steatosis may lead to suboptimal care of these patients.