The Effects of rPA Combined with Reduced Glutathione Hormone on Acute ST Segment Elevation Myocardial Infarction

Objective: To investigate the effect of the recombinant tissue plasminogen activato(rPA) combined with reduced glutathione hormone(GSH) on acute ST segment elevation myocardial infarction(STEMI).Method: 40 STEMI patients from our hospital in January 2010 to February 2012 were selected.They were divided into two groups One of the group were given routine thrombolytic therapy with rPA(rPA group,n=20),the other group were treated with rPA and GSH(rPA and GSH group,n=20).The recanalization rate,the change of myocardial enzyme spectrum,The improvement of heart function and the incidence of adverse reactions of the two groups before and after treatment were observed and compared.Results: ①Compared with before treatment,the myocardial enzymes levels of CK,AST,SOD,CK-MB,cTnT and cTnI significantly increased after treatment in both groups(P0.05 a11),but compared with the rPA group,the levels of myocardial enzymes were less,and SOD was more in GSH group(P0.05 a11);②Compared with routine thrombolysis group,there were significantly decreased in LVEDd [(53±5)mm vs(58±6)mm],LVESd[(41±5)mm vs(47±5)mm],and significantly increased in EF[(61±7)% vs(55±5)%] in the GSH group(P0.05 all);③The total incidence of adverse drug reactions in GSH groups was 5 patients(25%),significantly lower than that in the rPA group(P0.05).Conclusion: The rPA combined with reduced glutathione hormone can significantly increase the ST in patients with ST-elevation myocardial infarction vascular recanalization rate,improve ventricular structure and function after reperfusion,reduce the rate of complications.