Advances in Clinical Application of Pemetrexed for Abdominal Tumors

Pemetrexed is a novel multitargeted antifolate that inhibits several enzymes critical for thymidine and purine synthesis,and their inhibition,in turn,disrupts DNA and RNA synthesis. Pemetrexed possesses antitumor activity in several solid tumors,including malignant pleural mesothelioma,non-small cell lung cancer,pancreas cancer,colorectal cancer,gastric cancer,and breast cancer etc.. The main toxicities of the pemetrexed are myelosuppression,skin rash,and mucositis. Here is to make a review of the clinical application progress of pemetrexed as a single agent or in combination with other drugs for common abdominal tumor.