A novel technology for objective, accurate and non-invasive early diagnosis and monitoring of Alzheimer\'s disease in clinics and clinical trials

We have developed a novel medical image processing technology for objective, accurate, and non-invasive diagnosis, prognosis, and monitoring of Alzheimer9s disease using standard clinical brain MRI (magnetic resonance imaging) and basic clinical cognitive assessment. The technology is a robust, highly accurate, fully automated, high-throughput, cloud-based platform, which operates in a fully integrated and controlled environment. In diagnosis mode, our technology performs with 91% balanced accuracy on blind testing to diagnose the current neurocognitive status, and in prognosis mode, or early detection at mild cognitive impairment (MCI) stage, with 88% balanced accuracy on blind testing to predict progression from MCI to Alzheimer9s dementia (AD) within 5 years. Such prognostic capability is currently non-existent, even in specialty clinics and hospitals, a major factor in Alzheimer9s clinical trial failures. The algorithm9s diagnostic certainty precisely mirrors the diagnostic confidence of an expert cognitive neurologist for both MCI (Spearman9s Rho = 1) and AD (Rho = 1). In addition to widespread clinical applications, this novel technology can enable correct patient selection and therapeutic effect monitoring in clinical trials of Alzheimer9s disease, the crucial elements to finding a cure.