Examining the diagnostic validity of the Berlin Questionnaire in a low-income Black American sample.

Study objectives Black individuals and individuals of low socioeconomic status are at increased risk for obstructive sleep apnea (OSA). The Berlin Questionnaire is one of the most widely used screening tools for OSA; however, there is limited research on its diagnostic accuracy in low-income, Black populations. Methods This study analyzed data from an ongoing study taking place among a cohort from two predominantly Black neighborhoods in Pittsburgh, PA (96.3% Black, 79.6% female). The sample included 269 individuals without a prior diagnosis of OSA who completed the Berlin Questionnaire and also participated in a home sleep apnea test (HSAT). An apnea-hypopnea index (AHI) ≥ 15 was used to identify individuals with moderate or severe OSA. Results 19.3% of individuals met criteria for moderate to severe OSA based on HSAT, while 31.2% of participants screened as high risk for OSA based on the overall Berlin index. Using AHI>=15 as the reference standard, the Berlin Questionnaire had a sensitivity of 46.2%, specificity of 72.4%, positive predictive value (PPV) of 28.6%, and negative predictive value of 84.9% among this sample. Analyses stratified by sex suggested that the Berlin Questionnaire had better diagnostic validity in women than men. Conclusions The Berlin Questionnaire has lower sensitivity and PPV in our sample than those observed in general population samples. The measure performed better among women, though a higher proportion of men fell into the moderate or severe OSA range based on the HSAT. Given the significant downstream consequences of OSA, utilizing screening tools that better detect OSA in Black communities is key.