Cimetidine: A Gastroesophageal Reflux Antagonist?

Several studies have shown the beneficial effect of Cimetidine in gastroesophageal reflux disease (GERD) as regards the symptomatic, endoscopic, and to some extent also the histologic manifestations of this disease. Cimetidine up to a dose of 2 g daily has been used in the various trials reported [1–5].