Diagnostic value of combined detection of serum soluble complement receptor, Cystatin C, β2 microglobulin and urinary albumin on diabetic nephropathy

Objective To detect the levels of serum soluble complement receptor 1 (sCR1),cystatin C(CysC),β2 microglobulin(β2MG) and urine albumin(mAlb) in patients with diabetic nephropathy(DN),and study the effects of these factors on the diagnosis and treatment of diabetic nephropathy,in order to provide references for the early stage diagnosis and treatment of diabetic nephroathy.Methods Eighty-two DN patients were selected were chose as the experiment group and 65 healthy people as the control group.The serum level of sCR1 was detected by ELISA.The serum levels of CysC,β2MG and mAlb were measured by immunoturbidimetry.Then,the correlation of serum levels of sCR1,CysC,β2MG and mAlb with DN was analyzed.Results The serum level of sCR1 of DN patients was lower than that of healthy people.The levels of CysC,β2MG in serum and mAlb were higher in DN patients than that in healthy people (P ＜ 0.01).Conclusions The serum levels of sCR1,CysC,β2MG and mAlb are supplementary indicators for the progression of DN,suggesting that these factors may play an important role in the development of DN,so sCRI,cysc,β2 MG and mAlb can be used as supplementary monltoring indexes for the progression of DN. Key words: Serum soluble complement receptor 1 ; Cystatin C;  β2 microglobulin;  Urine albumin