Detection of clonal hematopoiesis of indeterminate potential in clinical sequencing of solid tumor specimens

TO THE EDITOR: Clonal hematopoiesis of indeterminate potential (CHIP) describes an expansion of hematopoietic stem cells that harbor somatic mutations[1][1][⇓][2][⇓][3][⇓][4]-[5][5] without an underlying hematologic malignancy or definitive morphologic evidence of dysplasia.[6][6] CHIP can