Prognostic Significance of Admission Systemic Inflammation Response Index in Patients With Spontaneous Intracerebral Hemorrhage: A Propensity Score Matching Analysis

Intracerebral hemorrhage (ICH) accounts for approximately 15% of all strokes and is associated with high mortality and disability rates. The systemic inflammation response index (SIRI) is a novel systemic inflammatory marker based on peripheral neutrophil, monocyte, and lymphocyte counts. This study aimed to evaluate the prognostic significance of admission SIRI in patients with spontaneous ICH and compare its predictive ability with that of the neutrophil to lymphocyte ratio (NLR). This retrospective study was conducted based on a prospectively collected database of patients with ICH between June 2016 and January 2019. Propensity score matching (PSM) was conducted to adjust for potential imbalances in the clinical parameters. A total of 403 patients were included in the original cohort. The optimal SIRI cut-off value was 2.76. After 1:1 PSM based on potential confounding variables, a new cohort containing 262 patients was established for further analysis. In the original cohort, SIRI served as an independent predictor of 3-month functional outcome (odds ratio [OR], 1.302; 95% confidence interval [CI], 1.1201.512; p = 0.001) and 1-month mortality (OR, 1.072; 95%CI, 1.0201.126; p = 0.006), while NLR was independently associated with only 3-month functional outcomes (OR, 1.051; 95%CI, 1.0041.100); p = 0.031 and not 1-month mortality. The same applied to the PSM cohort. Receiver operating characteristic analysis indicated that SIRI was superior to NLR in predicting the outcomes of patients with ICH. SIRI is determined to be an independent predictive indicator for ICH in patients with both 3-month functional outcomes and 1-month mortality. The prognostic predictive ability of SIRI was stronger than that of NLR.