Diagnostik und Therapie des Rektumkarzinoms

2010 
LBA4007. 17. Debucquoy A, Haustermans K, Daemen A, et al. Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer. J Clin Oncol. 2009;27:2751–7. Epub 2009 Mar 30. 18. MacFarlane JK, Ryall RD, Heald RJ. Mesorectal excision for rectal cancer. Lancet. 1993;341: 457–60. 19. Dahlberg M, Glimelius B, Pahlman L. Changing strategy for rectal cancer is associated with improved outcome. Br J Surg 1999;86:379–84. 20. West NP, Finan PJ, Anderin C, et al. Evidence of the oncologic superiority of cylindrical abdominoperineal excision for low rectal cancer. J Clin Oncol. 2008;26:3517–22. Epub 2008 Jun 9. 21. Andre T, Boni C, Navarro M, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol. 2009;27: 3109–16. Epub 2009 May 18. 22. NCCN Guidelines, rectal cancer, REC-4 23. http://www.cancer.gov/clinicaltrials/NSABP-C10. Fazit fur die Praxis Bei klinischem Stadium III eines Rektum-Karzinoms wird dem Patienten eine neoadjuvante Radiochemotherapie mit nachfolgender tiefer anteriorer Resektion und protektiver Ileostoma-Anlage sowie postoperativ eine adjuvante Chemotherapie empfohlen. PRAXIS 736
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