Not RESTing on Its Laurels: Timing and Mechanisms of HCN Channel Dysfunction in Epilepsy

), occurred in the dendrites of CA1 hippocampal pyramidal neurons after pilocarpine-induced status epilepticus (SE), accompanied by loss of HCN1 channel protein expression. However, the precise onset and mechanistic basis of HCN1 channel loss post-SE was unclear, particularly whether it preceded the onset of spontaneous recurrent seizures and could contribute to epilep-togenesis or development of the epileptic state. Here, we found that loss of I