RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND PHYSIOLOGICAL ACTION THE EFFECT OF 1-SUPRARENIN (SYNTHETIC EPINEPHRINE) AND VARIOUS DERIVATIVES UPON THE BLOOD SUGAR OF NORMAL RABBITS

From the foregoing results, it is evident that the hyperglycemic action of the compounds studied is in the following order of decreasing intensity: 1-suprarenin, dl-suprarenin, dl-methyl ether of suprarenin, d-Suprarenin, epinine, dl-ethyl ether of suprarenin, methylaminoacetopyrocatechol, the anhydride of suprarenin, tyramine and pyrocatechol. The importance of the secondary alcohol group in the configuration of the molecule is shown. Whether its orientation is such that the dextro- or the levo-form results, is also of importance. When substitution occurs or H 2 O is split out to form the anhydride, the effect upon the animal organism is altered as indicated by the decreased hyperglycemic action.