Serum pregnancy-associated plasma protein-A levels in a cohort with cardiovascular disease (1158.2)

Patients with acute coronary syndrome (ACS) who have high serum levels of pregnancy-associated plasma protein-A (PAPP-A) are at increased risk of cardiac events. PAPP-A levels have been reported to indicate elevated risk in ACS patients who were troponin I-negative. The long range goal is to assess changes in PAPP-A levels in a longitudinal study of subjects diagnosed with cardiovascular disease to further test the validity of serum levels of PAPP-A as a predictor of adverse cardiovascular events. Initial serum levels of PAPP-A were measured in a cohort of 243 subjects to establish the reference range for the cohort. Serum PAPP-A levels were measured using a commercial sandwich type immunoassay using dual wavelength colorimetric detection. Serum PAPP-A levels ranged from 0.43 to 4.2 ng/ml with geometric mean and 95% CI of 0.95 (0.87 - 0.97) ng/ml. A correction factor of 2.7 international units/ng PAPP-A was used to calculate the reference range in mIU/L (0.4 - 11). Median values of serum PAPP-A did not va...