Evaluation of Serum 25-hydroxyvitamin D Levels in Children with The First Episode of Seizures

BackgroundSeizures have been prevalent among children leading to critical complications and death in some cases, investigation of the reasons for seizures is of great importance. The aim of this investigation was to assess the influence of 25-hydroxyvitamin D deficiency on seizures.Materials and MethodsThis study was a case control study and carried out on 1 to 16-year-old children of Besat Hospital of Sanandaj, Kurdistan province, Iran, with the first episode of seizures (case) and children who were caming for routine laboratory checkup (control) in the year 2020.Serum 25-hydroxyvitamin D level was measured by chemiluminescence immunoassays methods of blood sample for both case &control groups. The required data were collected and entered in SPSS software version 21.0 to be analyzed. A p-value less than 0.05 was considered as the significance level.ResultsTotal individuals of 120 children (72 (60%)boys) with an average age of 46.77+40.5 months were selected for the investigation.Sixty-two patients(51.7%)of the children received an appropriate vitamin D supplement, and prevalence of vitamin D supplementation use was higher in case group(P=0.011).The average serum level of 25-hydroxyvitamin D in individuals was 31.36+19.01,and the average serum level of vitamin D in the patient group was greater than that of the control group(P=0.003).The frequency of 25-hydroxyvitamin D deficiency was higher in the control group(p=0.001).ConclusionBased on the obtained results, an important conclusion can be reached that seizures in children were not effectively prevent by normal vitamin D supplements.