The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stress.

Patrick M. Grierson,Paarth B Dodhiawala,Yi Cheng,Tim Hung-Po Chen,Iftikhar Ali Khawar,Qing Wei,Daoxiang Zhang,Lin Li,John M. Herndon,Joseph B. Monahan,Marianna B. Ruzinova,Kian-Huat Lim

The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stress.

2021

Patrick M. Grierson
Paarth B Dodhiawala
Yi Cheng
Tim Hung-Po Chen
Iftikhar Ali Khawar
Qing Wei
Daoxiang Zhang
Lin Li
John M. Herndon
Joseph B. Monahan
Marianna B. Ruzinova
Kian-Huat Lim

Combination chemotherapies remain the cornerstone treatment for pancreatic ductal adenocarcinoma (PDAC), but de novo and acquired resistance is common. In this study, we aimed to identify and chara...

Keywords:

Cancer research
Genotoxic Stress
acquired resistance
pancreatic ductal adenocarcinoma
Mechanism (biology)
Hsp27
Medicine

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